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My sister and I recently watched Fullmetal Alchemist: Brotherhood, and it was phenomenal! I cannot recommend this anime enough. I would say it is one of the greatest anime series ever produced, up there with Sailor Moon, Dragon Ball, and Neon Genesis Evangelion. Speaking of Evangelion, I noticed several references to it in this show, which makes me think the creator was inspired by it when writing this story.
What is the story? Two brothers, Edward and Alphonse Elric (Ed and Al for short), attempt to resurrect their dead mother but end up disfigured instead since they broke an alchemy taboo and the Law of Equivalent Exchange(TM) took effect. Ed loses his right arm and left leg, and Al loses his whole body. Ed saves Al's soul at the last minute, binding it to a suit of armor. The rest of the series is about them searching for a way to become whole again while learning about their estranged father and dealing with a mysterious evil force that lurks in the shadows.
You can stream this series on Netflix and Crunchyroll as well as buy a physical copy. I want to try to get this on Blu-ray in the future as this is media I feel is worth preserving.